144625-51-4
144625-51-4 structure
- Name: GR113808
- Chemical Name: [1-[2-(methanesulfonamido)ethyl]piperidin-4-yl]methyl 1-methylindole-3-carboxylate
- CAS Number: 144625-51-4
- Molecular Formula: C19H27N3O4S
- Molecular Weight: 393.50000
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-12-22 14:06:41
- Modify Date: 2024-01-16 18:47:01
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GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1].
| Name | [1-[2-(methanesulfonamido)ethyl]piperidin-4-yl]methyl 1-methylindole-3-carboxylate |
|---|---|
| Synonyms |
Clocinnamox mesylate
MFCD00912901 1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate |
| Description | GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1]. |
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| Related Catalog | |
| In Vivo | GR113808 (intraperitoneal injection; 1 mg/kg; 5-7 days starting 24 h after induction of colitis) shows a significant increase in the disease activity index (DAI),which includes evaluation of weight loss, stool consistency, and presence of fecal blood[2]. Animal Model: Mice[1] Dosage: 1 mg/Kg Administration: Intraperitoneal injection; 1 mg/Kg; 5-7 days starting 24 h after induction of colitis Result: Blocked protective effects of tegaserod after induction of colitis. |
| References |
| Density | 1.3g/cm3 |
|---|---|
| Boiling Point | 572.3ºC at 760 mmHg |
| Molecular Formula | C19H27N3O4S |
| Molecular Weight | 393.50000 |
| Flash Point | 299.9ºC |
| Exact Mass | 393.17200 |
| PSA | 89.02000 |
| LogP | 3.00590 |
| Vapour Pressure | 4.19E-13mmHg at 25°C |
| Index of Refraction | 1.613 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |