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107015-83-8

107015-83-8 structure

107015-83-8 structure

Name: Amyloid β-Protein (12-28)
Chemical Name: Amyloid β-Peptide (12-28) (human)
CAS Number: 107015-83-8
Molecular Formula: C₈₉H₁₃₅N₂₅O₂₅
Molecular Weight: 1955.18000
Catalog: Biochemical Peptide
Create Date: 2018-08-16 19:59:48
Modify Date: 2026-07-04 16:39:54
β-amyloid (12-28) is a 17-aa peptide fragment, which can produce amyloid aggregates, used in the research of Alzheimer’sdisease.

Name	Amyloid β-Peptide (12-28) (human)
Synonyms	AMYLOID BETA-PROTEIN VHHQKLVFFAEDVGSNK vhhqklvffaedvgsnk B-AMYLOID PROTEIN SYNTHETIC AMYLOID BETA-PROTEIN FRAGMENT Amyloidb-Ptide(human) Amyloid β-Protein amyloid b-protein fragment 12-28 Amyloid β-Protein /β-Amyloid BETA-AMYLOID AMyloid b-Protein MFCD00133075 AMYLOID, BETA- , HUMAN beta-Amyloid Ptide AMYLOID-BETA PROTEIN , HUMAN BETA-AMYLOID PTIDE , HUMAN β-amyloid L-Lysine, L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-asptyl-L-valylglycyl-L-seryl-L-aspaginyl Amyloid β-Ptide (human) Amyloid Bate-Protein /Bate-Amyloid ALZHEIMER'S DISEASE BETA-PROTEIN SP17 AMyloid β-Protein AlzheiMer's Disease β-Protein beta-Amyloid Ptide (TFA salt) AMYLOID BETA-PTIDE (HUMAN) β-amyloid (12-28) amyloid β-protein fragment Bate-Amyloid VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH //BP H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH AMYLOID B-PROTEIN FRAGMENT β-Amyloid protein fragment sp17 C89H135N25O25 AlzheiMer's Disease b-Protein m.w. 1955.20 c89h135n25o25

Description	β-amyloid (12-28) is a 17-aa peptide fragment, which can produce amyloid aggregates, used in the research of Alzheimer’sdisease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Neurological Disease Peptides
Target	Amyloid-β[1]
In Vitro	β-amyloid (12-28) preared freshly in solution has no cytotoxicity, but aged β12-28 peptide (0.001-40 μM) reduces the viability of PC12 cells in a concentration dependent manner[1].
Cell Assay	PC12 pheochromocytoma cell lines are routinely cultured in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum,5% horse serum, 1% glutamine and 1% penicillin/streptomycin. Exponentially growing cellsare plated at 30000 cells per well per 100 µL of fresh medium in 96-well tissue cultures plates. Toxicity assays are carried out by measurementof MTT reduction. Two days after plating PC12 pheochromocytoma cell lines are treated with different concentrations of aged β-amyloid (12-28). After 22 h, MTT (5 mg/mL) wasadded and incubation is continued for a further2 h. Cells are lysed and after 24 h at 37°C,colorimetric determination of MTT reduction is made at 550 nm. Positive controls consist of cells in culture medium. Assay values obtained with these controls are taken as 100% viability[1].
References	[1]. Rabanal F, et al. Structural, kinetic and cytotoxicity aspects of 12-28 beta-amyloid protein fragment: a reappraisal. J Pept Sci. 2002 Oct;8(10):578-88.

Molecular Formula	C₈₉H₁₃₅N₂₅O₂₅
Molecular Weight	1955.18000
Exact Mass	1954.01000
PSA	819.33000
LogP	2.72410
Storage condition	−20°C

WGK Germany	3

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