Amyloid β-Protein (12-28)

Modify Date: 2024-01-02 17:39:54

Amyloid β-Protein (12-28) Structure
Amyloid β-Protein (12-28) structure
Common Name Amyloid β-Protein (12-28)
CAS Number 107015-83-8 Molecular Weight 1955.18000
Density N/A Boiling Point N/A
Molecular Formula C89H135N25O25 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Amyloid β-Protein (12-28)


β-amyloid (12-28) is a 17-aa peptide fragment, which can produce amyloid aggregates, used in the research of Alzheimer’sdisease.

 Names

Name Amyloid β-Peptide (12-28) (human)
Synonym More Synonyms

 Amyloid β-Protein (12-28) Biological Activity

Description β-amyloid (12-28) is a 17-aa peptide fragment, which can produce amyloid aggregates, used in the research of Alzheimer’sdisease.
Related Catalog
Target

Amyloid-β[1]

In Vitro β-amyloid (12-28) preared freshly in solution has no cytotoxicity, but aged β12-28 peptide (0.001-40 μM) reduces the viability of PC12 cells in a concentration dependent manner[1].
Cell Assay PC12 pheochromocytoma cell lines are routinely cultured in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum,5% horse serum, 1% glutamine and 1% penicillin/streptomycin. Exponentially growing cellsare plated at 30000 cells per well per 100 µL of fresh medium in 96-well tissue cultures plates. Toxicity assays are carried out by measurementof MTT reduction. Two days after plating PC12 pheochromocytoma cell lines are treated with different concentrations of aged β-amyloid (12-28). After 22 h, MTT (5 mg/mL) wasadded and incubation is continued for a further2 h. Cells are lysed and after 24 h at 37°C,colorimetric determination of MTT reduction is made at 550 nm. Positive controls consist of cells in culture medium. Assay values obtained with these controls are taken as 100% viability[1].
References

[1]. Rabanal F, et al. Structural, kinetic and cytotoxicity aspects of 12-28 beta-amyloid protein fragment: a reappraisal. J Pept Sci. 2002 Oct;8(10):578-88.

 Chemical & Physical Properties

Molecular Formula C89H135N25O25
Molecular Weight 1955.18000
Exact Mass 1954.01000
PSA 819.33000
LogP 2.72410
Storage condition −20°C

 Safety Information

WGK Germany 3

 Synonyms

MFCD00133075
vhhqklvffaedvgsnk
sp17
amyloid b-protein fragment 12-28
m.w. 1955.20 c89h135n25o25
β-amyloid (12-28)
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