126738-34-9

126738-34-9 structure

Name: Sarafotoxin A
Chemical Name: Sarafotoxin S6a
CAS Number: 126738-34-9
Molecular Formula: C₁₀₅H₁₅₆N₂₈O₃₄S₅
Molecular Weight: 2514.85000
Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
Create Date: 2019-01-10 19:13:51
Modify Date: 2024-01-02 13:59:26
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM[1].

Name	Sarafotoxin S6a
Synonyms	SRTX-A,S6A M.W. 2514.85 C105H156N28O34S5 H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH CHPG Sodium salt CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP SARAFOTOXIN A SARAFOTOXIN S6A1

Description	Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Neurological Disease
Target	ETB ETA
In Vitro	Sarafotoxin S6a is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC50) is 150 nM in guinea-pig aorta[1].
References	[1]. P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol