160588-45-4

160588-45-4 structure

Name: DMP 543
Chemical Name: 10,10-bis[(2-fluoropyridin-4-yl)methyl]anthracen-9-one
CAS Number: 160588-45-4
Molecular Formula: C₂₆H₁₈F₂N₂O
Molecular Weight: 412.43
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-12-22 13:46:15
Modify Date: 2024-01-20 11:38:54
DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

Name	10,10-bis[(2-fluoropyridin-4-yl)methyl]anthracen-9-one
Synonyms	HMS3268N10 TCN 237 dihydrochloride DMP 543

Description	DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	KV7 channel
In Vitro	DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].
References	[1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.