96850-13-4
96850-13-4 structure
- Name: Indatraline hydrochloride
- Chemical Name: indatraline hydrochloride
- CAS Number: 96850-13-4
- Molecular Formula: C16H16Cl3N
- Molecular Weight: 328.66400
- Catalog: Signaling Pathways Neuronal Signaling Dopamine Transporter
- Create Date: 2017-07-19 02:51:05
- Modify Date: 2024-01-03 14:19:21
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Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine) with efficacy similar to cocaine. Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis[1].
| Name | indatraline hydrochloride |
|---|---|
| Synonyms | lu 19-005 |
| Description | Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine) with efficacy similar to cocaine. Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis[1]. |
|---|---|
| Related Catalog | |
| Target |
monoamine transporter[1] |
| In Vitro | Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3[1]. Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm[1]. Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC50 of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis[1]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 0~5 μM Incubation Time: 24 hours Result: Made the concentration-dependent conversion of LC3. Immunofluorescence[1] Cell Line: EGFP-LC3 stable cells Concentration: 1~10 μM Incubation Time: 24 hours Result: EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm. |
| In Vivo | Indatraline (2 μM) hydrochloride inhibits neointimal accumulation of smooth muscle cells[1]. |
| References |
| Molecular Formula | C16H16Cl3N |
|---|---|
| Molecular Weight | 328.66400 |
| Exact Mass | 327.03500 |
| PSA | 12.03000 |
| LogP | 5.98240 |
| Storage condition | 2-8°C |
