31721-17-2

31721-17-2 structure

Name: quinupramine
Chemical Name: 11-(1-azabicyclo[2.2.2]octan-3-yl)-5,6-dihydrobenzo[b][1]benzazepine
CAS Number: 31721-17-2
Molecular Formula: C₂₁H₂₄N₂
Molecular Weight: 304.43
Catalog: Research Areas Neurological Disease
Create Date: 2018-09-22 20:35:18
Modify Date: 2024-01-21 10:37:35
Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system[1][2].

Name	11-(1-azabicyclo[2.2.2]octan-3-yl)-5,6-dihydrobenzo[b][1]benzazepine
Synonyms	Quinupraminum Kinupril Kevopril Quinupramina Quinupramine

Description	Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vivo	Quinupramine (10 mg/kg, PO, twice daily for 10 days) causes a down-regulation of serotonin S2 receptors in the frontal cortex of the rat[2]. Quinupramine-EVA matrix containing a permeation enhancer can be a good transdermal delivery system for providing sustained plasma concentrations[3]. Animal Model: Sprague-Dawley rats (Male, 220-270 g) Dosage: 10 mg/kg Administration: PO, twice daily for 10 days Result: Caused a down-requlation of serotonin S2 receptors in the frontal cortex of the rat, did not alter the binding populations of Q-adrenergic, muscarinic cholinergic and a2-adrenergic receptors in the rat brain.
References	[1]. [1] Sakamoto H, et al. Effects of quinupramine on the central monoamine uptake systems and involvement of pharmacokinetics in its pharmacological activities. Jpn J Pharmacol. 1987;45(2):169-175. [2]. [2] Sakamoto H, et al. Down-regulation of central serotonin S2 receptors after repeated treatment with quinupramine in rats. Jpn J Pharmacol. 1987;43(4):369-377. [3]. [3] Shin SC, et al. Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. Pharm Dev Technol. 2007;12(5):429-436.

Density	1.19g/cm3
Boiling Point	445.2ºC at 760mmHg
Molecular Formula	C₂₁H₂₄N₂
Molecular Weight	304.43
Flash Point	201.7ºC
Exact Mass	304.19400
PSA	6.48000
LogP	4.02040
Index of Refraction	1.667

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

103548-41-0

~92%

31721-17-2

Literature: Barton, Derek H.R.; Fekih, Abdelwaheb; Lusinchi, Xavier Tetrahedron Letters, 1985 , vol. 26, # 38 p. 4603 - 4606

Precursor 1
103548-41-0
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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