Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SIS3
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521984-48-5

521984-48-5 structure

521984-48-5 structure

Name: SIS3
Chemical Name: sis3
CAS Number: 521984-48-5
Molecular Formula: C₂₈H₂₈ClN₃O₃
Molecular Weight: 489.993
Catalog: Signaling Pathways Stem Cell/Wnt TGF-beta/Smad
Create Date: 2016-06-26 20:55:15
Modify Date: 2026-07-17 10:15:47
SIS3 is a cell-permeable and selective inhibitor of Smad3. It inhibits Smad3 phosphorylation with an IC50 of 3 µM.

Name	sis3
Synonyms	(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride SIS3, Smad3 inhibitor myofibroblast,inhibit,TGF-β1,TGF-beta/Smad,(E)SIS3,Smad3,(E)-SIS3,Transforming owth factor beta,fibroblasts,differentiation,(E) SIS3,phosphorylation,(E)-SIS-3,Inhibitor SIS 3 HCL;SIS-3 HCL (2E)-1-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one hydrochloride (1:1) 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride 2-Propen-1-one,1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-,hydrochloride (1:1), (2E) Caneritinib(CI-1033) SIS3 HCl (E)-SIS3, 10 mM in DMSO Caneritinib SIS3 (SIS 3 (E)-1-[6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one Hydrochloride 2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)-, hydrochloride (1:1) SIS3 hydrochloride 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride

Description	SIS3 is a cell-permeable and selective inhibitor of Smad3. It inhibits Smad3 phosphorylation with an IC50 of 3 µM.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Research Areas >> Cancer
References	[1]. Boudreau HE et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82. [2]. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607. [3]. Di Bernardini E et al. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways. J Biol Chem. 2014 Feb 7;289(6):3383-93.

Boiling Point	737.2ºC at 760 mmHg
Molecular Formula	C₂₈H₂₈ClN₃O₃
Molecular Weight	489.993
Flash Point	399.7ºC
Exact Mass	489.181915
PSA	56.59000
LogP	5.59550
Storage condition	-20℃

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