Name | 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride |
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Synonyms |
1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride
1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride (1:1) 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol hydrochloride 1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrochloride (1:1) 1H-3-Benzazepine-7,8-diol,2,3,4,5-tetrahydro-1-phenyl-,hydrochloride SKF 38393 (hydrochloride) |
Description | SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.IC50 value: 110 nM [1]Target: D1 agonistin vitroL SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. SKF 38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. [2] |
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Related Catalog | |
References |
Molecular Formula | C16H18ClNO2 |
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Molecular Weight | 291.773 |
Exact Mass | 291.102600 |
PSA | 52.49000 |
LogP | 3.50620 |
Storage condition | -20℃ |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi |
Risk Phrases | 36/37/38 |
Safety Phrases | 22-26-36 |
RIDADR | NONH for all modes of transport |