628690-75-5

628690-75-5 structure

Name: TP 003
Chemical Name: tp-003
CAS Number: 628690-75-5
Molecular Formula: C₂₃H₁₆F₃N₃O
Molecular Weight: 407.38800
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2016-01-24 11:45:10
Modify Date: 2024-01-12 18:02:57
TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].

Name	tp-003

Description	TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Elena Neumann, et al. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA_A receptors. Neuropharmacology. 2018 Dec;143:71-78.