TP 003

Modify Date: 2025-08-27 06:09:29

TP 003 structure	Common Name	TP 003
	CAS Number	628690-75-5	Molecular Weight	407.38800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₁₆F₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TP 003

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].

Name	tp-003

Description	TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Elena Neumann, et al. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA_A receptors. Neuropharmacology. 2018 Dec;143:71-78.

Molecular Formula	C₂₃H₁₆F₃N₃O
Molecular Weight	407.38800
Exact Mass	407.12500
PSA	61.32000
LogP	5.18468
InChIKey	SJMMDWXJSSJHOQ-UHFFFAOYSA-N
SMILES	CC(C)(O)c1ccn2c(-c3ccc(F)c(-c4ccc(F)cc4C#N)c3)cnc2c1F

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Human GABAA receptor alpha5 subunit (GABAA receptors)
Source: IUPHAR-DB
Target: GABAA receptor alpha5 subunit (GABAA receptors) [Homo sapiens]
External Id: 408_Human

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: Human GABAA receptor alpha1 subunit (GABAA receptors)
Source: IUPHAR-DB
Target: GABAA receptor alpha1 subunit (GABAA receptors) [Homo sapiens]
External Id: 404_Human

Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582

Name: Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A7681

Name: Human GABAA receptor alpha3 subunit (GABAA receptors)
Source: IUPHAR-DB
Target: GABAA receptor alpha3 subunit (GABAA receptors) [Homo sapiens]
External Id: 406_Human

Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149

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China
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.