- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SubstancePFragment1-7
- Price:
- Purity: 97.0%
- Stocking Period: 10 Day
- Contact: Yang
- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Substance P: 1-7
- Price: $Inquiry/1g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: ARG-PRO-LYS-PRO-GLN-GLN-PHE
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
68060-49-1
68060-49-1 structure
- Name: Substance P (1-7)
- Chemical Name: ARG-PRO-LYS-PRO-GLN-GLN-PHE
- CAS Number: 68060-49-1
- Molecular Formula: C41H65N13O10
- Molecular Weight: 900.03600
- Catalog: Peptides
- Create Date: 2018-12-20 11:17:19
- Modify Date: 2024-01-05 20:50:14
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Substance P (7-11) is a fragment of the neuropeptide, substance P (SP). Substance P (7-11) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.
| Name | ARG-PRO-LYS-PRO-GLN-GLN-PHE |
|---|---|
| Synonyms |
2-[[5-amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoic acid
PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2: PKPQQFFGLM-NH2PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2: PKPQQFFGLM-NH2 ARG-PRO-LYS-PRO-GLN-GLN-PHE Substance P Fragment 1-7 Substance P (1-7) Substance P: 1-7 |
| Description | Substance P (7-11) is a fragment of the neuropeptide, substance P (SP). Substance P (7-11) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius. |
|---|---|
| Related Catalog | |
| In Vivo | Substance P (7-11) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (7-11) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P (7-11) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2]. |
| Animal Admin | Rats[1] Sprague-Dawley male rats weighing 250-300 g are anaesthetized with halothane and placed in a stereotaxic frame. An injection cannula, conically shaped with a penetration tip diameter of approximately 0.15 mm is loared into the SNR. Saline (0.2 μL), SP (0.007-0.7 nM) or Substance P (7-11) (0.01-1 nM) is injected into the left substantia nigra, pars reticulata (SNR) and the rat is placed in a rotometer. The substances are injected in a total volume of 0.2 μL over a period of 1 min. A group of animals is sacrificed by decapitation 1 hour after the injection, their brains are immediately removed and tissue samples are taken from left and right striatum, globus pallidum (GP) and substantia nigra (SN). Samples are assayed for SP and SP(1-7)[1]. Mice[2] The accumulated response time (s) of reciprocal movements of hindlimb scratching, biting, fore- and hindpaw licking are measured in Male mice (STD strain, 23-28 g) during the whole period of aversive response and 20 min at maximum. Substance P (7-11) is tested for its ability to inhibit the aversive response produced by intrathecal injection of SP or SP(5-11) (0.1 nM/mouse). Substance P (7-11) (1, 2, 4 pM) is then administered together with SP or SP(5-11)[2]. |
| References |
| Molecular Formula | C41H65N13O10 |
|---|---|
| Molecular Weight | 900.03600 |
| Exact Mass | 899.49800 |
| PSA | 394.44000 |
| LogP | 1.91700 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |