85421-89-2

85421-89-2 structure

Name: 6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-
Chemical Name: 2-amino-9-[3,4-dihydroxy-5-(1-hydroxyethyl)oxolan-2-yl]-3H-purin-6-one
CAS Number: 85421-89-2
Molecular Formula: C₁₁H₁₅N₅O₅
Molecular Weight: 297.27
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-06-16 16:56:30
Modify Date: 2024-01-19 16:56:00
5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	2-amino-9-[3,4-dihydroxy-5-(1-hydroxyethyl)oxolan-2-yl]-3H-purin-6-one

Description	5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.