6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-

Modify Date: 2024-01-19 16:56:00

6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro- structure	Common Name	6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-
	CAS Number	85421-89-2	Molecular Weight	297.27
	Density	2.11g/cm3	Boiling Point	744.3ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₅N₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	403.9ºC

Use of 6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-

5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	2-amino-9-[3,4-dihydroxy-5-(1-hydroxyethyl)oxolan-2-yl]-3H-purin-6-one

Description	5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Density	2.11g/cm3
Boiling Point	744.3ºC at 760 mmHg
Molecular Formula	C₁₁H₁₅N₅O₅
Molecular Weight	297.27
Flash Point	403.9ºC
Exact Mass	297.10700
PSA	159.51000
Index of Refraction	1.895

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6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-

Use of 6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-

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Chemical & Physical Properties