510721-85-4

510721-85-4 structure

Name: AR03
Chemical Name: 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine
CAS Number: 510721-85-4
Molecular Formula: C₁₅H₁₅N₃
Molecular Weight: 237.30
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2016-05-24 18:16:26
Modify Date: 2024-01-13 19:06:24
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].

Name	2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine
Synonyms	2,4,9-Trimethyl-benzo[b][1,8]naphthyridin-5-ylamine HMS2537D20

Description	AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	IC50: 2.1 µM (Ape1)[1]
References	[1]. Aditi Bapat, et al. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. J Pharmacol Exp Ther. 2010 Sep 1;334(3):988-98.

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%