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666-99-9

666-99-9 structure
666-99-9 structure
  • Name: agaric acid
  • Chemical Name: 2-hydroxynonadecane-1,2,3-tricarboxylic acid
  • CAS Number: 666-99-9
  • Molecular Formula: C22H40O7
  • Molecular Weight: 416.54900
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-06-17 08:02:40
  • Modify Date: 2024-01-06 17:47:00
  • Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism[1].

Name 2-hydroxynonadecane-1,2,3-tricarboxylic acid
Synonyms Laricic acid
n-Hexadecylcitric acid
EINECS 211-566-5
Agaricinic acid
(2S,3S)-2-Hydroxy-nonadecan-1,2,3-tricarbonsaeure
Lr-2-Hydroxy-nonadecan-1,2rF,3cF-tricarbonsaeure
Agaric acid
Agaricinsaeure
MFCD00002665
Agaricin
(2S,3S)-2-Hydroxy-nonadecan-1,2,3-tricarbonsaeure (Agaricinsaeure)
Agaricic acid
(2S,3S)-2-hydroxy-nonadecane-1,2,3-tricarboxylic acid
Description Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism[1].
References

[1]. García N, et al. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion. 2005 Aug;5(4):272-81.

Density 1.115g/cm3
Boiling Point 509.3ºC at 760 mmHg
Melting Point 142° (dec)
Molecular Formula C22H40O7
Molecular Weight 416.54900
Flash Point 275.9ºC
Exact Mass 416.27700
PSA 132.13000
LogP 4.84900
Index of Refraction 1.501

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RA5365000
CHEMICAL NAME :
1,2,3-Nonadecanetricarboxylic acid, 2-hydroxy-
CAS REGISTRY NUMBER :
666-99-9
BEILSTEIN REFERENCE NO. :
1729981
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H40-O7
MOLECULAR WEIGHT :
416.62
WISWESSER LINE NOTATION :
QVY16&XQVQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS RA5365000