Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Pyridinealdoxime methochloride
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Purity: 98.0%
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51-15-0

51-15-0 structure

Name: 2-Pyridinealdoxime methochloride
Chemical Name: pralidoxime chloride
CAS Number: 51-15-0
Molecular Formula: C₇H₉ClN₂O
Molecular Weight: 172.612
Catalog: API Special medicine Antidote
Create Date: 2018-06-02 08:00:00
Modify Date: 2026-07-04 21:52:18
Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents) in conjunction with atropine and diazepam.

Name	pralidoxime chloride
Synonyms	2-PYRIDINEALDOXIME METHOCHLORIDE 1-METHYLPYRIDINIUM-2-ALDOXIME CHLORIDE protopamchloride 1-Methylpyridinium-2-aldoximeChloride> Pyridinealdoxime methochloride 2-((Hydroxyimino)methyl)-1-methylpyridin-1-ium chloride N-Methylpyridinium-2-cboxaldoximechloride 1-methyl-2-formylpyridiniumchlorideoxime pyridinium, 2-[(hydroxyimino)methyl]-1-methyl-, chloride (1:1) 2-PYRIDINIUMALDOXIMEMETHOCHLORIDE Pyraloxime Pralidoxome Chloride Pralidoxime Chloride PYRIDINE-2-CBALDOXIME METHOCHLORIDE 2-PAM CHLORIDE 2-formyl-1-methylpyridiniumchlorideoxime PRALIDOXIME CHLORIDE Pralidoxime Chloride-API[PAM.Cl] 2-[(Hydroxyimino)methyl]-1-methylpyridiniumchloride 2-PAM chloride (Pyridine-2-aldoxime methochloride) Pralidoxime chloride, >= 2-[(Hydroxyimino)methyl]-1-methylpyridinium chloride Pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, chloride (1:1) Pyraloxime chloride 2-formyl-n-methylpyridiniumoximechloride n-methylpyridiniumchloride2-aldoxime Pyraloximi Methchlordum Pralidoxime chIoride IP pralidoxime 2-Hydroxyiminomethyl-1-methylpyridiniumchlorid pyridinium,2-formyl-1-methyl-,chloride,oxime pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, chloride 1-methyl-2-aldoximinopyridiniumchloride MFCD00011981 pyraloxime methylchloride (1-methyl-2-pyridinylidene)methyl-oxoammonium chloride Protopam PRALIDOXIMECHLORIDE pyridiniumaldoximemethochloride PYRIDINE-2-ALDOXIME METHOCHLORIDE protopam Pyralidoxime Methylchloride 2-pyridine-aldoximechloride EINECS 200-080-9 2-[hydroxyimino ethyl]-1-methylpyridinium chloride PYRIDINE-2-CBOXALDOXIME METHOCHLORIDE 2-PAM chloride, Pralidoxime chloride PRALIDOXIMECHLORIDE,USP 2-PAM-Cl 1-methyl-2-pyridiniumaldoximechloride n-metylpyridinium-2-aldoximechloride PAM CHLORIDE PAM-CL 1-methyl-2-pyridine aldoxyme chloride Pralidoxime chloride - Bio-X 2-[(E)-(Hydroxyimino)methyl]-1-methylpyridinium chloride 2-Pyridine aldoxime methyl chloride N-METHYLPYRIDINIUM-2-ALDOXIME CHLORIDE 2-(hydroxyiminomethyl)-1-methylpyridiniumchloride PraHdoxime Methytchloride Pyridine-2-aldoxiMe Meth Pvraloximi Chloridum Pralidoxime Chloride //BP N-Methylpyridinium-2-cboxaldoxime chloride~2-PAM chloride~Pralidoxime chloride~Pyridine-2-aldoxime methochloride 1-MethylpyridiniuM-2-aldoxiMe Chloride 2-pyridinealdoximemethylchloride 2-((hydroxyimino)methyl)-1-methyl-pyridiniuchloride 2-Pyridinealdoxime 1-methochloride

Description	Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents) in conjunction with atropine and diazepam.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease

Boiling Point	189.7ºC at760mmHg
Melting Point	215-225 ºC
Molecular Formula	C₇H₉ClN₂O
Molecular Weight	172.612
Flash Point	68.5ºC
Exact Mass	172.040344
PSA	36.47000
Storage condition	0-6°C
Water Solubility	65.5 g/100 mL (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU4200000

CHEMICAL NAME :: Pyridinium, 2-formyl-1-methyl-, chloride, oxime

CAS REGISTRY NUMBER :: 51-15-0

LAST UPDATED :: 199603

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C7-H9-N2-O.Cl

MOLECULAR WEIGHT :: 172.63

WISWESSER LINE NOTATION :: T6KJ A1 B1UNQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - bronchiolar constriction Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,449,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 15,599,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,40,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,40,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 155 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,5,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,5,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,431,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S106,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 132,50,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 168 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,40,1970 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 50,475,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6078 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 968 (estimated) No. of Female Employees: 494 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P261-P280-P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/22;R36/37/38
Safety Phrases	S36-S37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UU4200000
HS Code	2933399090

154-97-2

~90%

51-15-0

Literature: Unnisa, Lateef; Sumakanth; Rao, B. Leelamaheswara; Divi, Murali Krishnaprasad; Rao, Mysore Aswathanarayana Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014 , vol. 53, # 4 p. 431 - 435

70275-57-9

~89%

51-15-0

873-69-8

51-15-0

Precursor 3
154-97-2 70275-57-9 873-69-8
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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