30918-54-8
30918-54-8 structure
- Name: Polyinosinic acid
- Chemical Name: 5'-Inosinic acid polymers
- CAS Number: 30918-54-8
- Molecular Formula: C10H13N4O8P
- Molecular Weight: 348.206
- Catalog: Biochemical Biological response modifier
- Create Date: 2018-05-13 08:00:00
- Modify Date: 2024-01-03 12:57:00
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Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation[1].
| Name | 5'-Inosinic acid polymers |
|---|---|
| Synonyms |
(1S)-1,4-Anhydro-1-(6-oxo-6,7-dihydro-1H-purin-8-yl)-5-O-phosphono-D-ribitol
Polyinosinic acid (Poly I) (1S)-1,4-Anhydro-1-(6-oxo-6,9-dihydro-3H-purin-8-yl)-5-O-phosphono-D-ribitol Polyinosinicacid POLY[I] POTASSIUM SALT POLY RL POTASSIUM SALT D-Ribitol, 1,4-anhydro-1-C-(6,9-dihydro-6-oxo-3H-purin-8-yl)-, 5-(dihydrogen phosphate), (1S)- Polyinosinic acid Poly(rI) Poly(IMP) polyinosinicacidpot.salt |
| Description | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Polyinosinic acid (50 µg/mL；24 h) 诱导 BALB/c B 细胞中 CD86、CD40 和 MHC II 的表达，BALB/c BMDC 细胞中 CD86 和 CD40 的表达[1]。 Polyinosinic acid (1、5 和 25 µg/mL；48 h) 以剂量依赖性方式加强了 BALB/c B 细胞对 [3H] 胸苷的摄取[1]。 Polyinosinic acid (50 µg/mL；20 h) 诱导 BALB/c BMDC 细胞和巨噬细胞分泌 TNFα 和 IL-12，BALB/c B 细胞、BMDC 细胞分泌 IFN。Polyinosinic acid 增加了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞中 MHC II、CD86 的表达[1]。 Polyinosinic acid (50 µg/mL；48 h) 加强了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞对胸苷的摄取[1]。 Polyinosinic acid (25 µg/mL 和 50 µg/mL；24 h) 以剂量依赖性方式诱导 BEAS-2B 细胞分泌 IP-10[1]。 Polyinosinic acid (50 µg/mL；24 h 或 48 h) 通过 TRIF 调节 TRIF+/+ 和 TRIF-/- 小鼠 B 细胞中 CD86 的表达及胸苷的摄取[1]。 Polyinosinic acid (10、20 或 50 µg/mL；20 h) 增加了 TLR3+/+ 来源的 BMDC 细胞分泌 IFN 和 IFNα，但不影响 TLR3-/- 来源的 BMDC 细胞[1]。 |
| References |
| Density | 2.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 905.4±75.0 °C at 760 mmHg |
| Molecular Formula | C10H13N4O8P |
| Molecular Weight | 348.206 |
| Flash Point | 501.4±37.1 °C |
| Exact Mass | 348.047089 |
| PSA | 189.83000 |
| LogP | -2.65 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.918 |
| Storage condition | −20°C |
| WGK Germany | 3 |
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