4981-83-3

4981-83-3 structure

Name: Benzyl-PEG1-Tos
Chemical Name: 2-(benzyloxy)ethyl 4-methylbenzenesulfonate (en)Ethanol, 2-(phenylmethoxy)-, 4-methylbenzenesulfonate (en)
CAS Number: 4981-83-3
Molecular Formula: C₁₆H₁₈O₄S
Molecular Weight: 306.37700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-04-23 09:10:14
Modify Date: 2024-01-09 16:11:23
Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(benzyloxy)ethyl 4-methylbenzenesulfonate (en)Ethanol, 2-(phenylmethoxy)-, 4-methylbenzenesulfonate (en)
Synonyms	1-benzyloxy-2-tosyloxyethane 2-benzyloxyethyl p-toluenesulfonate 2-Benzyl-Oxyethyl Chloroformate 1-O-benzyl-2-O-p-toluenesulfonyl ethylene glycol

Description	Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

622-08-2

98-59-9

~98%

4981-83-3

Literature: Curiel, David; Beer, Paul D.; Tarraga, Alberto; Molina, Pedro Chemistry - A European Journal, 2009 , vol. 15, # 31 p. 7534 - 7538

622-08-2

98-59-9

54555-84-9

4981-83-3

Literature: Sankyo Company Limited Patent: US4012429 A1, 1977 ;

100-44-7

4981-83-3

Literature: Ghosh, Suhrit; Ramakrishnan Angewandte Chemie - International Edition, 2005 , vol. 44, # 34 p. 5441 - 5447

30379-55-6

4981-83-3

20194-18-7

4981-83-3

100-39-0

4981-83-3

Literature: Zammit, Charlotte M.; Wills, Martin Tetrahedron Asymmetry, 2013 , vol. 24, # 13-14 p. 844 - 852