Benzyl-PEG1-Tos
Benzyl-PEG1-Tos structure
|
Common Name | Benzyl-PEG1-Tos | ||
|---|---|---|---|---|
| CAS Number | 4981-83-3 | Molecular Weight | 306.37700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H18O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Benzyl-PEG1-TosBenzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 2-(benzyloxy)ethyl 4-methylbenzenesulfonate (en)Ethanol, 2-(phenylmethoxy)-, 4-methylbenzenesulfonate (en) |
|---|---|
| Synonym | More Synonyms |
| Description | Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C16H18O4S |
|---|---|
| Molecular Weight | 306.37700 |
| Exact Mass | 306.09300 |
| PSA | 60.98000 |
| LogP | 3.99790 |
|
~98%
Benzyl-PEG1-Tos CAS#:4981-83-3 |
| Literature: Curiel, David; Beer, Paul D.; Tarraga, Alberto; Molina, Pedro Chemistry - A European Journal, 2009 , vol. 15, # 31 p. 7534 - 7538 |
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Benzyl-PEG1-Tos CAS#:4981-83-3 |
| Literature: Sankyo Company Limited Patent: US4012429 A1, 1977 ; |
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Benzyl-PEG1-Tos CAS#:4981-83-3 |
| Literature: Ghosh, Suhrit; Ramakrishnan Angewandte Chemie - International Edition, 2005 , vol. 44, # 34 p. 5441 - 5447 |
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Benzyl-PEG1-Tos CAS#:4981-83-3 |
| Literature: Campbell, John B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1213 - 1218 |
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Benzyl-PEG1-Tos CAS#:4981-83-3 |
| Literature: Campbell, John B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1213 - 1218 |
|
~%
Benzyl-PEG1-Tos CAS#:4981-83-3 |
| Literature: Zammit, Charlotte M.; Wills, Martin Tetrahedron Asymmetry, 2013 , vol. 24, # 13-14 p. 844 - 852 |
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