26328-11-0
26328-11-0 structure
- Name: AGI-001
- Chemical Name: (S)-(-)-pindolol
- CAS Number: 26328-11-0
- Molecular Formula: C14H20N2O2
- Molecular Weight: 248.32100
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2017-05-07 00:19:32
- Modify Date: 2024-01-10 17:36:29
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l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease[1][2][3].
| Name | (S)-(-)-pindolol |
|---|---|
| Synonyms |
Tocris-1060
(2S)-1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol DL-AP4 Sodium salt |
| Description | l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | l-Pindolol (500 nM 和 1 μM) 拮抗 5-羧胺色胺 (5-CT；10 nM) 和 5-羟色胺 (5-HT；15 μM) 通过检测 5-CT 和 5-HT 对 CA1 锥体细胞的膜超极化[1]。 l-Pindolol (1 nM-100 μM) 抑制 100 nM 5-CT 诱导的 CA1 锥体细胞超极化，IC50 值为 92 nM[1]。 l-Pindolol (1 nM-100 μM) 抑制 300 nM 5-CT 引起的 CA3 神经元超极化，IC50 值为 522 nM[1]。 |
| In Vivo | l-Pindolol (15 mg/kg；腹腔注射，[3H]-WAY 100635 注射前预处理) 减少了 [3H]-WAY 100635 在含有 5-HT1A 受体的脑区的积累。 Animal Model: Male Sprague Dawley rats[1] Dosage: 15 mg/kg Administration: Intraperitoneal injection; 15 mg/kg, 20 min acute treatment or 24 h, 16 h and 20 min short-term treatment before [3H]-WAY 100635 injection Result: Reduced [3H]-WAY 100635 accumulation in 5-HT1A receptor-containing brain areas, but showed no effect on the dorsal raphe nucleus (DRN), and the CA1 and CA3 hippocampal areas. |
| Density | 1.152g/cm3 |
|---|---|
| Boiling Point | 457.1ºC at 760mmHg |
| Molecular Formula | C14H20N2O2 |
| Molecular Weight | 248.32100 |
| Exact Mass | 248.15200 |
| PSA | 57.28000 |
| LogP | 2.29650 |
| Vapour Pressure | 3.77E-09mmHg at 25°C |
| Index of Refraction | 1.596 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |