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26473-08-5

26473-08-5 structure
26473-08-5 structure
  • Name: 1,4-(2H6)Naphthalenedione
  • Chemical Name: 1,4-naphthoquinone-d6
  • CAS Number: 26473-08-5
  • Molecular Formula: C10D6O2
  • Molecular Weight: 164.190
  • Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
  • Create Date: 2018-07-25 17:47:37
  • Modify Date: 2024-01-12 01:04:11
  • 1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].
Name 1,4-naphthoquinone-d6
Synonyms Hexadeuterio-1,4-naphthoquinone
2.3-dicyano-1,4-naphtho-quinone
2,3-dicyano-1,4-napthoquinone
2,3-dicyanonaphtho-1,4-quinone
Hexadeuteronaphtha-1,4-chinon
1,4-dioxo-1,4-dihydronaphthalene-2,3-dicarbonitrile
1,4<D6>-Naphthochinon
(H)Naphthalene-1,4-dione
1,4-(H)Naphthalenedione
1,4-Naphthalenedione-d
1,4-naphthoquinone-2,3-dicarbonitrile
<D6>-1,4-Naphthochinon
Description 1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Coelho-Cerqueira E, et al. Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase. Chem Biol Drug Des. 2014 Apr;83(4):401-10.  

Density 1.3±0.1 g/cm3
Boiling Point 297.9±40.0 °C at 760 mmHg
Molecular Formula C10D6O2
Molecular Weight 164.190
Flash Point 111.2±24.3 °C
Exact Mass 164.074432
PSA 34.14000
LogP 1.79
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.617
Precursor  1

DownStream  0


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title: CAS No. 26473-08-5 | Chemsrc address: https://m.chemsrc.com/en/baike/1117984.html

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