269390-69-4

269390-69-4 structure

Name: N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE
Chemical Name: N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide
CAS Number: 269390-69-4
Molecular Formula: C₁₉H₁₆ClN₃O
Molecular Weight: 337.80300
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2017-10-21 14:13:04
Modify Date: 2024-01-03 00:46:37
VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].

Name	N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide
Synonyms	HMS3229O07 VEGF Receptor Tyrosine Kinase Inhibitor II

Description	VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
Target	KDR:0.02 μM (IC50) Flt-1:0.18 μM (IC50) EGFR:0.24 μM (IC50)
References	[1]. Furet P, et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett. 2003;13(18):2967-2971.