N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE

Modify Date: 2025-08-26 18:41:33

N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE Structure
N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE structure
Common Name N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE
CAS Number 269390-69-4 Molecular Weight 337.80300
Density N/A Boiling Point N/A
Molecular Formula C19H16ClN3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE


VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].

 Names

Name N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide
Synonym More Synonyms

  Biological Activity

Description VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].
Related Catalog
Target

KDR:0.02 μM (IC50)

Flt-1:0.18 μM (IC50)

EGFR:0.24 μM (IC50)

References

[1]. Furet P, et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett. 2003;13(18):2967-2971.

 Chemical & Physical Properties

Molecular Formula C19H16ClN3O
Molecular Weight 337.80300
Exact Mass 337.09800
PSA 54.02000
LogP 4.74540

 Synonyms

HMS3229O07
VEGF Receptor Tyrosine Kinase Inhibitor II
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