DC Chemicals Limited
China
Product Name: 8-OH-DPAT
Price: $450.0/100mg $800.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

78950-78-4

78950-78-4 structure

78950-78-4 structure

Name: 8-OH-DPAT
Chemical Name: 8-hydroxy-2-(di-n-propylamino)tetralin
CAS Number: 78950-78-4
Molecular Formula: C₁₆H₂₅NO
Molecular Weight: 247.37600
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-12-28 13:05:03
Modify Date: 2024-01-08 19:36:55
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).

Name	8-hydroxy-2-(di-n-propylamino)tetralin
Synonyms	2-dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene (+/-)-2-dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene (+/-)-2-dirpopylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene 8-OH-2-(di-n-propylamino)-1,2,3,4-tetrahydronaphthalene 3-(Dipropylamino)Tetralin-5-Ol 8-OH-DPAT

Description	8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
Target	pIC50: 8.19 (5-HT1A)[1] Ki: 466 nM (5-HT7)[2]
In Vitro	8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5)[1]. 8-OH-DPAT has high affinity at 5-HT7 with a Ki of 466 nM, and does not bind to 5-HT6 or 5-HT4[2].
In Vivo	8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice[3].
Animal Admin	Mice[3] The locomotor activity of mice is measured by an infrared sensor placed in individual home cages. To compare the locomotor activity in the light and dark periods, locomotor activity is monitored at 30-min intervals starting at 8:00 a.m. and 8:00 p.m., respectively. To measure the effects of psychostimulants (8-OH-DPAT, 1, 3 mg/kg, s.c; etc.) on locomotor activity in the dark period, all drugs are administered at 8:00 p.m., and locomotor activity is then measured through 3 h[3].
References	[1]. DEREK N. MIDDLEMISS, et al. 8-HYDROXY-2-(DI-n-PROPYLAMINO)-TETRALIN DISCRIMINATES BETWEEN SUBTYPES OF [2]. Bard JA, et al. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. [3]. Mori T, et al. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT. Psychopharmacology (Berl). 2016 Jun;233(12):2343-53.

Boiling Point	372.5ºC at 760 mmHg
Molecular Formula	C₁₆H₂₅NO
Molecular Weight	247.37600
Flash Point	168.2ºC
Exact Mass	247.19400
PSA	23.47000
LogP	3.37150
Storage condition	-20℃

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport