1092788-09-4

1092788-09-4 structure

Name: 3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide
Chemical Name: 3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide
CAS Number: 1092788-09-4
Molecular Formula: C₁₈H₁₉N₇OS
Molecular Weight: 381.45500
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2017-04-04 05:16:31
Modify Date: 2024-01-04 19:02:41
PP30, a TORKinib, is a potent, selective, and ATP-competitive inhibitor of mTOR with an IC50 of 80 nM.

Name	3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide

Description	PP30, a TORKinib, is a potent, selective, and ATP-competitive inhibitor of mTOR with an IC50 of 80 nM.
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	p110δ:0.99 μM (IC50) p110γ:0.68 μM (IC50)
References	[1]. Morris E Feldman, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10;7(2):e38.