3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide

Modify Date: 2024-01-04 19:02:41

3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide structure	Common Name	3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide
	CAS Number	1092788-09-4	Molecular Weight	381.45500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₉N₇OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide

PP30, a TORKinib, is a potent, selective, and ATP-competitive inhibitor of mTOR with an IC50 of 80 nM.

Name	3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide

Description	PP30, a TORKinib, is a potent, selective, and ATP-competitive inhibitor of mTOR with an IC50 of 80 nM.
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	p110δ:0.99 μM (IC50) p110γ:0.68 μM (IC50)
References	[1]. Morris E Feldman, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10;7(2):e38.

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