125256-00-0

125256-00-0 structure

Name: Fatostatin A
Chemical Name: 4-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine
CAS Number: 125256-00-0
Molecular Formula: C₁₈H₁₈N₂S
Molecular Weight: 294.41400
Catalog: Research Areas Cancer
Create Date: 2018-06-12 18:24:17
Modify Date: 2024-01-30 20:50:37
Fatostatin A is a inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cellstarget: SREBPIC50: 2.5 ~10 μMIn vitro: Fatostatin A suppress cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. [1] Fatostatin potently inhibited cell growth.[2]In vivo: Fatostatin A cause G2/M cell cycle arrest and induce apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. [1] μCT analyses show that fatostatin A treatment preserve bone mass and structure in the proximal tibial trabecular bone in the mouse RANKL-induced bone loss model.[3]

Name	4-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine
Synonyms	Hexatype Brown N Typogen Brown N Resinol RRN Solvent Brown 1 fatostatin A Sudan Brown YR Sudan Brown RR Fat Brown RR 1-naphthylamin->m-phenylendiamin C.I. Solvent Brown 1 4-naphthalen-1-yl-diazenyl-benzene-1,3-diamine Lithofor Brown A

Description	Fatostatin A is a inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cellstarget: SREBPIC50: 2.5 ~10 μMIn vitro: Fatostatin A suppress cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. [1] Fatostatin potently inhibited cell growth.[2]In vivo: Fatostatin A cause G2/M cell cycle arrest and induce apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. [1] μCT analyses show that fatostatin A treatment preserve bone mass and structure in the proximal tibial trabecular bone in the mouse RANKL-induced bone loss model.[3]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Li X et al. Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling. Mol Cancer Ther. 2014 Apr;13(4):855-66. [2]. Shao W et al. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res. 2016 Aug;57(8):1564-73. [3]. Inoue K et al. Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation. Biochim Biophys Acta. 2015 Nov;1852(11):2432-41.

HS Code	2934100090

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%