186826-17-5

186826-17-5 structure

Name: ML 10302 hydrochloride
Chemical Name: 2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride
CAS Number: 186826-17-5
Molecular Formula: C₁₅H₂₂Cl₂N₂O₃
Molecular Weight: 349.25300
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-04-17 06:13:58
Modify Date: 2024-01-09 20:24:24
ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM。ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].

Name	2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride

Description	ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM。ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT4 Receptor:4 nM (EC50)
In Vitro	ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay[1].
References	[1]. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436. [2]. D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21.