252979-43-4

252979-43-4 structure

Name: MRE 3008F20
Chemical Name: 1-[2-(2-Furyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]p yrimidin-5-yl]-3-(4-methoxyphenyl)ure
CAS Number: 252979-43-4
Molecular Formula: C₂₁H₂₀N₈O₃
Molecular Weight: 432.44
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2016-04-09 05:40:02
Modify Date: 2024-01-14 14:37:21
MRE3008F20 is a highly potent and selective antagonistic of adenosine A3 receptor (AA3R), inhibits agonist-induced cAMP elevation in resting T lymphocytes with an IC50 of 5 nM[1].

Name	1-[2-(2-Furyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]p yrimidin-5-yl]-3-(4-methoxyphenyl)ure

Description	MRE3008F20 is a highly potent and selective antagonistic of adenosine A3 receptor (AA3R), inhibits agonist-induced cAMP elevation in resting T lymphocytes with an IC50 of 5 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	IC50 : 5 nM (AA3R, resting T lymphocytes)[1]
References	[1]. Gessi S, et al. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol. 2004 Mar;65(3):711-9.