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61563-24-4

61563-24-4 structure
61563-24-4 structure
  • Name: Isoquinoline, 7,9-dichloro-1,2,3,4-tetrahydro-
  • Chemical Name: 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
  • CAS Number: 61563-24-4
  • Molecular Formula: C9H9Cl2N
  • Molecular Weight: 202.08000
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-12-31 13:26:35
  • Modify Date: 2024-01-02 15:13:41
  • 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1].
Name 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
Synonyms 7,8-Dichlor-1,2,3,4-tetrahydroisochinolin
1yz3
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
SK&SKA
Description 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1].
Related Catalog
In Vivo 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats[2]. Animal Model: Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats[2] Dosage: 40 mg/kg Administration: i.p.; once daily; 3 days Result: Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats. Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats.
References

[1]. Pramod C Nair, et al. Using Theory to Reconcile Experiment: The Structural and Thermodynamic Basis of Ligand Recognition by Phenylethanolamine N-Methyltransferase (PNMT). J Chem Theory Comput. 2011 May 10;7(5):1458-68.

[2]. N Y Liang, et al. Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure. J Pharmacol Exp Ther. 1982 Nov;223(2):382-7.
Density 1.293g/cm3
Boiling Point 310.7ºC at 760 mmHg
Molecular Formula C9H9Cl2N
Molecular Weight 202.08000
Flash Point 141.7ºC
Exact Mass 201.01100
PSA 12.03000
LogP 2.96790
Index of Refraction 1.574
HS Code 2933499090
HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 61563-24-4 | Chemsrc address: https://m.chemsrc.com/en/baike/1122969.html

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