623165-93-5
623165-93-5 structure
- Name: MRK 003
- Chemical Name: MRK 003
- CAS Number: 623165-93-5
- Molecular Formula: C25H31F6N3O2S
- Molecular Weight: 551.588
- Create Date: 2018-10-21 17:02:04
- Modify Date: 2023-01-14 07:06:24
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MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma.
| Name | MRK 003 |
|---|---|
| Synonyms |
(3'R,6S,9R)-5'-(2,2,2-trifluoroethyl)-2-((E)-3-(4-(trifluoromethyl)piperidin-1-yl)prop-1-en-1-yl)-5,6,7,8,9,10-hexahydrospiro[6,9-methanobenzo[8]annulene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide
(1'R,3R,10'S)-5-(2,2,2-Trifluoroethyl)-5'-{(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl}spiro[1,2,5-thiadiazolidine-3,13'-tricyclo[8.2.1.0]trideca[3,5,7]triene] 1,1-dioxide (6S,9R,11R)-5'-(2,2,2-trifluoroethyl)-2-{(1E)-3-[4-(trifluoromethyl)piperidin-1-yl]prop-1-en-1-yl}-5,6,7,8,9,10-hexahydrospiro[6,9-methanobenzo[8]annulene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.3±60.0 °C at 760 mmHg |
| Molecular Formula | C25H31F6N3O2S |
| Molecular Weight | 551.588 |
| Flash Point | 311.4±32.9 °C |
| Exact Mass | 551.204102 |
| PSA | 61.03000 |
| LogP | 4.74 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.568 |