1246817-46-8

1246817-46-8 structure

Name: 5-Hydroxy Rosiglitazone-d4
Chemical Name: 5-[[4-[1,1,2,2-tetradeuterio-2-[(5-hydroxypyridin-2-yl)-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CAS Number: 1246817-46-8
Molecular Formula: C₁₈H₁₅D₄N₃O₄S
Molecular Weight: 377.45
Create Date: 2016-06-26 22:22:06
Modify Date: 2024-01-03 10:21:07

Name	5-[[4-[1,1,2,2-tetradeuterio-2-[(5-hydroxypyridin-2-yl)-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Synonyms	5-Hydroxy Rosiglitazone-d4 5-[[4-[2-[(5-Hydroxy-2-pyridinyl)methylamino]ethoxy-d4]phenylmethyl]-2,4-thiazolidinedione

Description	5-Hydroxy Rosiglitazone-d4 是 5-Hydroxy Rosiglitazone氘代物[1]。
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.