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62802-77-1

62802-77-1 structure

62802-77-1 structure

Name: VEGFR-2-IN-29
Chemical Name: 3-nitro-N-quinolin-8-ylbenzamide
CAS Number: 62802-77-1
Molecular Formula: C₁₆H₁₁N₃O₃
Molecular Weight: 293.27700
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2017-07-22 11:01:29
Modify Date: 2025-08-27 10:18:01
VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].

Name	3-nitro-N-quinolin-8-ylbenzamide
Synonyms	3-Nitro-N-(8-chinolinyl)benzamid 3-Nitro-N-quinolin-8-yl-benzamide

Description	VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR-2:16.5 nM (IC50)
In Vitro	VEGFR-2-IN-29 (Compound 5) (72 h) inhibits HUVEC proliferation[1]. Cell Proliferation Assay[1] Cell Line: HUVEC Concentration: Incubation Time: 72 h Result: Showed inhibition with IC50s of 15.8 nM and 210 nM against VEGF- and bFGF-induced HUVEC proliferation.
References	[1]. Yang Y, et al. Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6653-6.

Molecular Formula	C₁₆H₁₁N₃O₃
Molecular Weight	293.27700
Exact Mass	293.08000
PSA	91.30000
LogP	4.30250

578-66-5 structure

578-66-5

121-92-6 structure

121-92-6

~87%

62802-77-1 structure

62802-77-1

Literature: Yang, Ying; Shi, Lei; Zhou, Yang; Li, Huan-Qiu; Zhu, Zhen-Wei; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6653 - 6656

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