VEGFR-2-IN-29

Modify Date: 2024-01-10 12:19:49

Use of VEGFR-2-IN-29

VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].

Name	3-nitro-N-quinolin-8-ylbenzamide
Synonym	More Synonyms

Description	VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR-2:16.5 nM (IC50)
In Vitro	VEGFR-2-IN-29 (Compound 5) (72 h) inhibits HUVEC proliferation[1]. Cell Proliferation Assay[1] Cell Line: HUVEC Concentration: Incubation Time: 72 h Result: Showed inhibition with IC50s of 15.8 nM and 210 nM against VEGF- and bFGF-induced HUVEC proliferation.
References	[1]. Yang Y, et al. Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6653-6.

8-Aminoquinoline

CAS#:578-66-5

3-Nitrobenzoic acid

CAS#:121-92-6

~87%

VEGFR-2-IN-29

CAS#:62802-77-1

Literature: Yang, Ying; Shi, Lei; Zhou, Yang; Li, Huan-Qiu; Zhu, Zhen-Wei; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6653 - 6656

3-Nitro-N-(8-chinolinyl)benzamid

3-Nitro-N-quinolin-8-yl-benzamide