75220-84-7

75220-84-7 structure

Name: Anticonvulsant agent 2
Chemical Name: 4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine
CAS Number: 75220-84-7
Molecular Formula: C₂₁H₁₇ClN₂
Molecular Weight: 332.83
Catalog: Research Areas Neurological Disease
Create Date: 2017-03-13 00:37:36
Modify Date: 2024-01-29 16:49:18
Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity[1].

Name	4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine

Description	Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Anticonvulsant agent 2 (compound10 a; 50 mg/kg, p.o.) 降低大鼠运动活性，抑制率为 21.01%[1]。 Anticonvulsant agent 2 (50 mg/kg; p.o.) 显示出抗癫痫活性，对大鼠的抑制率为24.45%[1]。 Animal Model: 180-250g, male Wistar rats[1] Dosage: 50 mg/kg Administration: P.o. Result: Showed antiepileptic activity with the inhibition rate of 24.45%.
References	[1]. Verma R, et al. Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents. Bioorg Chem. 2020 Aug;101:104010.

Molecular Formula	C₂₁H₁₇ClN₂
Molecular Weight	332.83
Exact Mass	332.10800
PSA	24.39000
LogP	5.59130

22966-22-9

95-54-5

~90%

75220-84-7

Literature: Du, Yuying; Tian, Fuli Journal of Chemical Research, 2006 , # 8 p. 486 - 489

95-54-5

956-02-5

~59%

75220-84-7

Literature: Orlov, V. D.; Kolos, N. N.; Yaremenko, F. G.; Lavrushin, V. F. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 5 p. 547 - 550 Khimiya Geterotsiklicheskikh Soedinenii, 1980 , # 5 p. 697 - 700

99-91-2

75220-84-7

Literature: Verma, Anil K.; Koul, Summon; Razdan, Tej K.; Kapoor, Kamal K. Canadian Journal of Chemistry, 2006 , vol. 84, # 8 p. 1064 - 1073

100-52-7

75220-84-7

Literature: Verma, Anil K.; Koul, Summon; Razdan, Tej K.; Kapoor, Kamal K. Canadian Journal of Chemistry, 2006 , vol. 84, # 8 p. 1064 - 1073

Precursor 5
22966-22-9 95-54-5 956-02-5 99-91-2
100-52-7
DownStream 1
716-79-0

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4