Shanghai Nianxing Industrial Co., Ltd
China
Product Name: N3-C5-NHSester
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Purity: 98.0%
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866363-70-4

866363-70-4 structure

866363-70-4 structure

Name: N3-C5-NHS ester
Chemical Name: (2,5-dioxopyrrolidin-1-yl) 6-azidohexanoate
CAS Number: 866363-70-4
Molecular Formula: C₁₀H₁₄N₄O₄
Molecular Weight: 254.24300
Catalog: Research Areas Cancer
Create Date: 2017-11-12 01:55:55
Modify Date: 2025-08-25 11:24:31
N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Name	(2,5-dioxopyrrolidin-1-yl) 6-azidohexanoate
Synonyms	6-azidohexanoic acid N-hydroxysuccinimide ester 6-azidohexanoic acid succinimidyl ester 2,5-dioxopyrrolidin-1-yl 6-azidohexanoate 2,5-Pyrrolidinedione,1-[(6-azido-1-oxohexyl)oxy] N-(6-azidohexanoyl)succinimide succinimidyl 6-azidohexanoate

Description	N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog	Research Areas >> Cancer
Target	Noncleavable
References	[1]. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

Molecular Formula	C₁₀H₁₄N₄O₄
Molecular Weight	254.24300
Exact Mass	254.10200
PSA	113.43000
LogP	0.85496

6066-82-6 structure

6066-82-6

79598-53-1 structure

79598-53-1

~95%

866363-70-4 structure

866363-70-4

Literature: Vasilyeva, Svetlana V.; Silnikov, Vladimir N.; Shatskaya, Natalia V.; Levina, Asya S.; Repkova, Marina N.; Zarytova, Valentina F. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 3 p. 703 - 711

4224-70-8 structure

4224-70-8

~%

866363-70-4 structure

866363-70-4

Literature: Grandjean, Cyrille; Boutonnier, Alain; Guerreiro, Catherine; Fournier, Jean-Michel; Mulard, Laurence A. Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7123 - 7132

Precursor 3
6066-82-6 79598-53-1 4224-70-8
DownStream 0

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