35189-28-7

35189-28-7 structure

Name: Norgestimate
Chemical Name: norgestimate
CAS Number: 35189-28-7
Molecular Formula: C₂₃H₃₁NO₃
Molecular Weight: 369.497
Catalog: API Hormone and endocrine-regulating drugs Birth control pills
Create Date: 2018-05-17 08:00:00
Modify Date: 2024-01-02 10:38:08
Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].

Name	norgestimate
Synonyms	(3E,8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (+)-13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-20-yn-3-one Oxime Acetate (Ester) d-17beta-acetoxy-13beta-ethyl-17alpha-ethinyl-gon-4en-3-one oxime dexnorgestrelacetime Norgestimat Norgestimate NORGESTIMATE,USP STANDARD levonorgestrel acetate 3-oxime (3E,8R,9S,10R,13S,14S,17R)-17-Ethinyl-13-ethyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ylacetat acétate de (3E,8R,9S,10R,13S,14S,17R)-13-éthyl-17-éthynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yle

Description	Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology
In Vitro	Norgestimate is converted to at least two active metabolites: levonorgestrel 3-oxime (deacetylated norgestimate; norelgestromin) and levonorgestrel[1].
References	[1]. Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68(10-13):879-90. [2]. Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167(4 Pt 2):1191-6.

CHEMICAL NAME :: 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)-

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,541,1977

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H315-H319-H361fd
Precautionary Statements	P281-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	63-22-36/38-62
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport
RTECS	JF7976000

13732-69-9

~85%

35189-28-7

Literature: RICHTER GEDEON VEGYESZETI GYAR R.T. Patent: WO2005/868 A1, 2005 ; Location in patent: Page/Page column 5 ;

Precursor 1
13732-69-9
DownStream 0