91374-21-9

91374-21-9 structure

Name: Ropinirole
Chemical Name: ropinirole
CAS Number: 91374-21-9
Molecular Formula: C₁₆H₁₇D₇N₂O
Molecular Weight: 260.375
Catalog: API Nervous system medication Anti-shock palsy
Create Date: 2018-03-27 08:00:00
Modify Date: 2024-01-02 11:37:06
Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].

Name	ropinirole
Synonyms	Ropinirole Unii-030pyr8953 MFCD00864147 2H-Indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro- Ropinirolum 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one ROPINIROLE INTERMEIDATES:

Description	Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor:29 nM (Ki) hD2 Receptor:7.4 (pEC50) hD3 Receptor:8.4 (pEC50) hD4.4 Receptor:6.8 (pEC50)
In Vitro	Ropinirole has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2].
In Vivo	Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2].
References	[1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54. [2]. Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17(12):1981-93.

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36/37/39