CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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PA5250000
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CHEMICAL NAME :
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Methane, bromochloro-
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CAS REGISTRY NUMBER :
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74-97-5
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BEILSTEIN REFERENCE NO. :
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1730801
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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40
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MOLECULAR FORMULA :
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C-H2-Br-Cl
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MOLECULAR WEIGHT :
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129.39
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WISWESSER LINE NOTATION :
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G1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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28800 ppm/15M
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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4300 mg/kg
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TOXIC EFFECTS :
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Behavioral - general anesthetic
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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12030 mg/m3/7H
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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>20 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1000 ppm/7H/16W-I
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TOXIC EFFECTS :
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Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - changes in metals, not otherwise specified
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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500 ppm/6H/26W-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in metals, not otherwise specified
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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500 ppm/6H/26W-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - changes in metals, not otherwise specified
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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1000 ppm/7H/16W-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - changes in metals, not otherwise specified
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Lung
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REFERENCE :
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TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 13,205,1987 *** REVIEWS *** ACGIH TLV-TWA 1060 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 200 ppm (1050 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,50,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1300 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-FINLAND:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1315 mg/m3) JAN 1993 OEL-FRANCE:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (1050 mg/m3);STEL 400 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (1050 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLOROBROMOMETHANE-air:10H TWA 200 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18250 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 56 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18250 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 71 (estimated)
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