57961-90-7
57961-90-7 structure
- Name: Centhaquin
- Chemical Name: 2-[2-[4-(3-methylphenyl)piperazin-1-yl]ethyl]quinoline
- CAS Number: 57961-90-7
- Molecular Formula: C22H25N3
- Molecular Weight: 331.45400
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2017-10-11 23:18:34
- Modify Date: 2024-01-03 11:33:01
-
Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models[1][2].
| Name | 2-[2-[4-(3-methylphenyl)piperazin-1-yl]ethyl]quinoline |
|---|---|
| Synonyms |
Centhaquin
Centhaquine Compound 7173 |
| Description | Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | Centhaquine (Centhaquin) (intravenous injection, 0.01-1.0 mg/kg; intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner[1]. Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci[1]. Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of catecholamines, improving both the macro- and microcirculation during CPR[2]. Animal Model: Landrace/Large White piglets[2] Dosage: 0.015mg/kg Administration: Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg Result: Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest. |
| References |
| Density | 1.124g/cm3 |
|---|---|
| Boiling Point | 499ºC at 760mmHg |
| Molecular Formula | C22H25N3 |
| Molecular Weight | 331.45400 |
| Flash Point | 255.6ºC |
| Exact Mass | 331.20500 |
| PSA | 19.37000 |
| LogP | 3.91080 |
| Index of Refraction | 1.628 |
|
~75%
57961-90-7 |
| Literature: PHARMAZZ, INC.; MIDWESTERN UNIVERSITY; GULATI, Anil; LAVHALE, Manish, S.; ANDURKAR, Shridhar, V. Patent: WO2014/35446 A1, 2014 ; Location in patent: Paragraph 0063 ; |
|
~%
57961-90-7 |
| Literature: Murti; Bhandari; Ram; Prabhakar; Saxena; Jain; Gulati; Srimal; Dhawan; Nityanand; Anand Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 11 p. 934 - 942 |
|
~%
57961-90-7 |
| Literature: Murti; Bhandari; Ram; Prabhakar; Saxena; Jain; Gulati; Srimal; Dhawan; Nityanand; Anand Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 11 p. 934 - 942 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |