21561-09-1

21561-09-1 structure

Name: WHI-P258
Chemical Name: 6,7-dimethoxy-N-phenylquinazolin-4-amine
CAS Number: 21561-09-1
Molecular Formula: C₁₆H₁₅N₃O₂
Molecular Weight: 281.309
Catalog: Signaling Pathways MAPK/ERK Pathway JNK
Create Date: 2016-08-18 02:54:28
Modify Date: 2024-01-17 19:49:12
WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].

Name	6,7-dimethoxy-N-phenylquinazolin-4-amine
Synonyms	4-Anilino-6,7-dimethoxychinazolin 6,7-dimethoxy-4-phenylaminoquinazoline HMS1662N04 4-anilino-6,7-dimethoxyquinazoline 4-quinazolinamine, 6,7-dimethoxy-N-phenyl- 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE WHI-P258

Description	WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> JNK
References	[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.

74497-02-2

13790-39-1

~99%

21561-09-1

5653-40-7

21561-09-1

13794-72-4

21561-09-1

Precursor 3
13790-39-1 5653-40-7 13794-72-4
DownStream 0