1190848-23-7

1190848-23-7 structure

Name: Fluorobexarotene
Chemical Name: 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoic acid
CAS Number: 1190848-23-7
Molecular Formula: C₂₄H₂₇FO₂
Molecular Weight: 366.46800
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2017-07-25 11:47:19
Modify Date: 2024-01-08 18:31:58
Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene[1].

Name	2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoic acid
Synonyms	Fluorobexarotene Teijin compound 1

Description	Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RXRα:12 nM (Ki) RXRα:43 nM (EC50)
References	[1]. Wagner CE, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct 8;52(19):5950-66.