1143516-05-5

1143516-05-5 structure

Name: AEEA-AEEA
Chemical Name: 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid
CAS Number: 1143516-05-5
Molecular Formula: C₁₂H₂₄N₂O₇
Molecular Weight: 308.32800
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2017-11-11 23:13:58
Modify Date: 2024-01-04 18:49:31
AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Name	17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid
Synonyms	17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic acid AEEA-AEEA

Description	AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.