461000-66-8
461000-66-8 structure
- Name: Eact
- Chemical Name: N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-3,4,5-trimethoxybenzeneacetamide
- CAS Number: 461000-66-8
- Molecular Formula: C22H24N2O5S
- Molecular Weight: 428.50100
- Create Date: 2017-11-03 05:01:26
- Modify Date: 2024-01-08 22:36:52
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Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity[1].
| Name | N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-3,4,5-trimethoxybenzeneacetamide |
|---|---|
| Synonyms | MFCD03115431 |
| Description | Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity[1]. |
|---|---|
| In Vitro | Eact elicits both itch-and pain- related behaviours in a TRPV1-dependent manner. Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner with an EC50 of 11.6 ± 2.5 μM. TMEM16A activator Eact activates both native and recombinant TRPV1 channels[1]. |
| References |
| Density | 1.237±0.06 g/cm3(Predicted) |
|---|---|
| Boiling Point | 595.9±60.0 ℃(Predicted) |
| Molecular Formula | C22H24N2O5S |
| Molecular Weight | 428.50100 |
| Exact Mass | 428.14100 |
| PSA | 98.36000 |
| LogP | 4.12910 |
| Storage condition | 2-8°C |
