944561-44-8

944561-44-8 structure

Name: Propargyl-PEG2-amine
Chemical Name: 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
CAS Number: 944561-44-8
Molecular Formula: C₇H₁₃NO₂
Molecular Weight: 143.18400
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-08-19 11:19:24
Modify Date: 2025-09-19 10:05:05
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

Name	2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
Synonyms	2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine 2-(2-(prop-2-ynyloxy)ethoxy)ethanamine

Description	Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable PEGs
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A. [2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.

RIDADR	2735.0
Hazard Class	8.0