Propargyl-PEG2-amine

Modify Date: 2024-01-03 19:05:46

Propargyl-PEG2-amine structure	Common Name	Propargyl-PEG2-amine
	CAS Number	944561-44-8	Molecular Weight	143.18400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇H₁₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Propargyl-PEG2-amine

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

Name	2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
Synonym	More Synonyms

Description	Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable PEGs
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A. [2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.

Molecular Formula	C₇H₁₃NO₂
Molecular Weight	143.18400
Exact Mass	143.09500
PSA	44.48000
LogP	0.31180
Storage condition	2-8°C

RIDADR	2735.0
Hazard Class	8.0

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine

2-(2-(prop-2-ynyloxy)ethoxy)ethanamine

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Propargyl-PEG2-amine
Price: ￥1328.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Propargyl-PEG2-amine
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-[2-(2-Propynyloxy)ethoxy]ethylamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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