5116-24-5

5116-24-5 structure

Name: 5-Hydroxymethyl-2'-deoxyuridine
Chemical Name: 5-hydroxymethyl-2'-deoxyuridine
CAS Number: 5116-24-5
Molecular Formula: C₁₀H₁₄N₂O₆
Molecular Weight: 258.228
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-04-01 08:00:00
Modify Date: 2026-07-01 17:05:27
5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3].

Name	5-hydroxymethyl-2'-deoxyuridine
Synonyms	2’-deoxy-5-(hydroxymethyl)-uridin 5-HMdU α-Hydroxythymidine 5-HMdU HMdUdr 5-HYDROXYMETHYL-2'-DEOXYURIDINE //BP 1-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-hydroxymethyl-1H-pyrimidine-2,4-dione 5-hydroxymethyl-2'-dU 2’-deoxy-5-(hydroxymethyl)uridine HMdUdr 2'-Deoxy-5-hydroxymethyluridine 5-Hydroxymethyl-2’-deoxyuridine, Antiviral and anticancer agent 5-hydroxymethyldeoxyuridine 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione alpha-hydroxythymidine 5-HYDROXYMETHYL-2'-DEOXYURIDINE Thymidine, α-hydroxy 5-Hydroxymethyl-2'-deoxyuridine, -hydroxythymidine 1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-methylol-pyrimidine-2,4-quinone 5-Hydroxymethyldeoxyuridine, 10 mM in DMSO [(1S,9-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-yl]methanol 1-(2-Deoxypentofuranosyl)-5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione 5-Hydroxymethyl-2’-deoxyuridine, Antiviral and anticancer agent,oxidative DNA damage product 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(hydroxymethyl)pyrimidine-2,4-dione 5-HYDROXYMETHYL-2'-D 1-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(hydroxymethyl)pyrimidine-2,4-dione oxidative DNA damage product 5 Hydroxymethyldeoxyuridine,5Hydroxymethyldeoxyuridine 1-(2-deoxypentofuranosyl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Description	5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
In Vitro	5-Hydroxymethyl-2'-deoxyuridine (0-10 μM) inhibits the replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells with ED50 values of 8.5 and 4 μM, respectively[1]. 5-Hydroxymethyl-2'-deoxyuridine inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase with a Ki value of 3.5 μM[1]. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM[2]. 5-Hydroxymethyl-2'-deoxyuridine (10-100 μM) shows dose-dependent toxicity against a human acute promyelocytic leukemia cell line[2].
In Vivo	5-Hydroxymethyl-2'-deoxyuridine (0, 5 and 50 mg/kg; i.p.; once) increases the survival of DBA/2 mice carrying L1210 leukemia[3].

TOXIC EFFECTS :: Gastrointestinal - other changes Related to Chronic Data - death

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 373,125,1997

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%