5116-24-5
5116-24-5 structure
- Name: 5-Hydroxymethyl-2'-deoxyuridine
- Chemical Name: 5-hydroxymethyl-2'-deoxyuridine
- CAS Number: 5116-24-5
- Molecular Formula: C10H14N2O6
- Molecular Weight: 258.228
- Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
- Create Date: 2018-04-01 08:00:00
- Modify Date: 2024-01-15 08:07:03
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5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3].
| Name | 5-hydroxymethyl-2'-deoxyuridine |
|---|---|
| Synonyms |
1-(2-Deoxypentofuranosyl)-5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxypentofuranosyl)-5-(hydroxymethyl)- 5-HMdU HMdUdr 1-(2-deoxypentofuranosyl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione 5-HYDROXYMETHYL-2'-DEOXYURIDINE |
| Description | 5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3]. |
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| Related Catalog | |
| In Vitro | 5-Hydroxymethyl-2'-deoxyuridine (0-10 μM) inhibits the replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells with ED50 values of 8.5 and 4 μM, respectively[1]. 5-Hydroxymethyl-2'-deoxyuridine inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase with a Ki value of 3.5 μM[1]. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM[2]. 5-Hydroxymethyl-2'-deoxyuridine (10-100 μM) shows dose-dependent toxicity against a human acute promyelocytic leukemia cell line[2]. |
| In Vivo | 5-Hydroxymethyl-2'-deoxyuridine (0, 5 and 50 mg/kg; i.p.; once) increases the survival of DBA/2 mice carrying L1210 leukemia[3]. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 401.48°C (rough estimate) |
| Melting Point | 176-179 °C |
| Molecular Formula | C10H14N2O6 |
| Molecular Weight | 258.228 |
| Exact Mass | 258.085175 |
| PSA | 124.78000 |
| LogP | -1.49 |
| Index of Refraction | 1.610 |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |