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115956-13-3

115956-13-3 structure
115956-13-3 structure
  • Name: Dolasetron (Mesylate)
  • Chemical Name: Dolasetron mesylate hydrate
  • CAS Number: 115956-13-3
  • Molecular Formula: C20H24N2O6S
  • Molecular Weight: 420.48
  • Catalog: API Digestive system medication Antiemetic emetic
  • Create Date: 2018-03-03 08:00:00
  • Modify Date: 2024-01-02 18:28:11
  • Dolasetron Mesylate (MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
Name Dolasetron mesylate hydrate
Synonyms (1r,3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
MFCD01718979
Dolasetron mesylate
(3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
1H-Indole-3-carboxylic acid, (6R,9aS)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, methanesulfonate, hydrate (1:1:1)
EINECS 214-599-3
Dolasetron (Mesylate)
Boiling Point 535.1ºC at 760 mmHg
Molecular Formula C20H24N2O6S
Molecular Weight 420.48
Flash Point 277.4ºC
PSA 134.38000
LogP 2.97740
Vapour Pressure 1.65E-22mmHg at 25°C
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL6015300
CHEMICAL NAME :
1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)-, monomethanesulfonate, monohydrate
CAS REGISTRY NUMBER :
115956-13-3
LAST UPDATED :
199801
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C19-H20-N2-O3.C-H4-O3-S.H2-O
MOLECULAR WEIGHT :
438.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 ug/kg
TOXIC EFFECTS :
Behavioral - headache Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes
REFERENCE :
BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 ug/kg/10M-C
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - headache
REFERENCE :
BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
545 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
165 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993
Risk Phrases R20/21/22

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title: CAS No. 115956-13-3 | Chemsrc address: https://m.chemsrc.com/en/baike/1189807.html

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