CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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WH6850000
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CHEMICAL NAME :
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Stannane, chlorotrimethyl-
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CAS REGISTRY NUMBER :
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1066-45-1
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LAST UPDATED :
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199801
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DATA ITEMS CITED :
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48
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MOLECULAR FORMULA :
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C3-H9-Cl-Sn
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MOLECULAR WEIGHT :
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199.26
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WISWESSER LINE NOTATION :
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G-SN-1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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12600 ug/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - excitement Behavioral - aggression
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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7450 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1800 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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3 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - aggression Gastrointestinal - hypermotility, diarrhea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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3 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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3 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - gerbil
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DOSE/DURATION :
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3 mg/kg
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TOXIC EFFECTS :
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Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4500 ug/kg/6D-I
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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63 mg/kg/2W-C
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Endocrine - changes in spleen weight Endocrine - changes in thymus weight
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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10 mg/kg/25D-I
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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8 mg/kg/8D-I
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Metabolism (Intermediary) - lipids including transport
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3 mg/kg/2D-I
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TOXIC EFFECTS :
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Endocrine - other changes Endocrine - changes in adrenal weight
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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9066 ug/kg
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SEX/DURATION :
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female 14 day(s) pre-mating - 21 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - behavioral
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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9 mg/kg
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SEX/DURATION :
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female 17 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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9 mg/kg
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SEX/DURATION :
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female 12 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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5 mg/kg
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SEX/DURATION :
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female 12 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - behavioral
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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9 mg/kg
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SEX/DURATION :
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female 17 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - other effects Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
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TYPE OF TEST :
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DNA inhibition
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TEST SYSTEM :
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Rodent - rabbit Cells - not otherwise specified
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REFERENCE :
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JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 16,229,1985 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,258,1971 OSHA PEL (Gen Indu):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.1 mg(Sn)/m3;STEL 0.3 mg(Sn)/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 mg(Sn)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL-THAILAND:TWA 0.1 mg(Sn)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1 mg(Sn)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
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